Matrix Metalloproteinase Expression Significance on Oral squamous cell carcinoma Clinical Outcome

Introduction:Oral Squamous Cell Carcinoma (OSCC) is an invasive neoplasm with a high prevalence. Matrix Metalloproteinase (MMP) has been thought to play an important role in both the invasion and metastasis of tumors. The aim of this study was to explore the significance of MMPs expression in clinical outcome of these patients. Materials:The most recognized data Bases such as PubMed, Google scholar, etc  were searched using keywords as OSCC, MMP, prognosis, clinical outcome, stage and other related ones During 1999 to 2019. Result:Among 24 reviewed in this study, MMP-9 was reported in association with invasion, metastasis recurrence, prognosis and patient survival in 7 ones but in no association with survival in only 1 research. Also, it is reported MMP-2 incorporation with poor differentiation, invasion and metastasis of OSCC in 5 studies, MMP-7 in relation with biological behavior, invasion and metastasis in 3 ones, MMP-1and 10 as indicators of OSCC cancer risk and also potential oral cancer markers in 2 studies, MT1-MMP in association with prognosis and patient survival in 3 research and in relation with invasion and metastasis in only 1 study. 3 studies suggested MMP family was associated with prognosis and metastasis of OSCC. MMP 28 and 12 were also evaluated in 2 studies and researches could not find any correlation with them and any clinical evaluated parameters. Conclusion:MMP 2, 7&9 is considered to have relation with clinical outcome but MMP 1 & 10 might be related to early consequences occurred in this field as indicators for initiation of OSCC.